PanTracer LBx is a liquid biopsy next-generation sequencing panel for advanced stage pan-solid tumor indications. The assay detects single nucleotide variants (SNV), insertions/deletions (InDels), copy number variants (CNV), and fusions in a total of 514 genes, plus microsatellite instability status (MSI-High status) and blood tumor mutational burden score (bTMB).
GENE LIST:
SNVs AND INDELS
ABL1, ABL2, ACVR1, ACVR1B, AKT1, …..
FUSIONS
ABL1, ALK, BCR, BRAF, CD74, EGFR, ETV1, ETV4, ETV6, EWSR1, FGFR2, FGFR3, NAB2, NTRK1, NTRK2, NUTM1, PAX3, PAX8, PPARG, RET, ROS1, TFE3, TMPRSS2
CNVs
AKT2, ALK, AR, ATM, BRAF, BRCA1, BRCA2, CCND1, CCND3, CCNE1, CDK4, CDK6, CHEK1, CHEK2, EGFR, ERBB2, ERBB3, ERCC1, ERCC2, ESR1, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, JAK2, KIT, KRAS, LAMP1, MDM2, MDM4, MET, MYCL, MYCN, NRAS, NRG1, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PTEN, RAF1, RET, RICTOR, RPS6KB1, TFRC